Oxycodone vs Hydrocodone are two of the most commonly prescribed opioids for managing moderate to severe pain, but they have key differences patients should understand. Both medications work by binding to opioid receptors in the brain to reduce pain signals, yet their potency, side effects, and risks vary. Oxycodone is often considered stronger and may provide longer-lasting relief, while Hydrocodone is frequently combined with acetaminophen for effective short-term pain management.
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