Tadalista 60 mg, which contains tadalafil, should typically be taken at least 30 to 60 minutes before sexual activity. However, its effects last much longer than other ED medications — up to 36 hours — so you have a flexible window. Best timing: 30 to 60 minutes before sex Effective window: Up to 36 hours You don’t need to rush sex immediately after taking it — many men find it works anytime during that 1–2 day window. Tadalista 60 mg is a very high dose — the usual maximum daily dose of tadalafil is 20 mg. 60 mg is not generally recommended unless prescribed specifically for certain cases and closely monitored by a doctor. If you're using Tadalista frequently, you might discuss with your doctor the option of a lower daily dose (e.g., 2.5 mg or 5 mg daily tadalafil), which can offer more consistent readiness and fewer side effects.