Malegra 100mg, which contains sildenafil citrate, is typically safe for most men when used occasionally and under medical supervision. However, long-term use may lead to certain effects. Physical tolerance is rare, but some men may find they need higher doses over time. Potential long-term side effects include headaches, nasal congestion, flushing, or indigestion. Rare but serious issues can involve vision changes, hearing loss, or priapism (a prolonged, painful erection). Additionally, psychological dependence can occur, where users feel unable to perform sexually without the medication. Individuals with heart conditions or on nitrates should be cautious. Always consult a doctor if Malegra is used regularly, to monitor health and avoid complications.