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Trimethylsilyl Trifluoromethanesulfonate | Cas N0: 27607-77-8 | India | Manufacturer

Started by mallalieu069 Jun 01st, 2024 at 02:24
mallalieu069
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Posts: 3
Jun 01st, 2024 at 02:24

Commencement

Trimethylsilyl trifluoromethanesulfonate (TMSOTf), a versatile organosilicon compound, is widely employed in organic synthesis. Triflates, organic derivatives of trifluoromethanesulfonic acid (CF3SO3H), are recognized for their propensity to function as highly effective electrophiles in various chemical reactions. This substance is classified as a triflate.

Chemical Composition

Composed of a trimethylsilyl group [(CH3)3Si-] and a triflate group (CF3SO3), TMSOTf is denoted by the chemical formula (CH3)3SiOTf. The molecule's distinctive reactivity due to its structure renders it advantageous in an extensive array of synthetic transformations.

Physical characteristics

TMSOTf is an odourless liquid that is noxious and piercing. Its molecular weight is approximately 282.31 g/mol at atmospheric pressure, and its boiling point is around 100°C. Due to its high reactivity, the compound must be handled with extreme caution.

The manufacturing procedure

The synthesis of TMSOTf(Cas N0: 27607-77-8) generally involves the anhydrous reaction of trimethylsilyl chloride (Me3SiCl) and triflic acid (CF3SO3H). As the reaction continues, the triflate group replaces the chloride, producing TMSOTf as a byproduct in addition to hydrochloric acid.

Solubility

Multiple organic solvents, such as dichloromethane, diethyl ether, and tetrahydrofuran, solubilize TMSOTf. Water's hydrophobic characteristics restrict its solubility.

Property details

As a triflate derivative, TMSOTf demonstrates an assertive electrophilic nature, rendering it a valuable reagent in organic synthesis. As a Lewis acid catalyst, it is frequently employed in many chemical reactions, such as nucleophilic substitutions, cyclization, and Friedel-Crafts acylation. Moreover, TMSOTf can function as a protective group against amines and alcohols, thereby enabling the execution of selective transformations.

 

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Safety and Management

Due to its high reactivity, TMSOTf must be handled with extreme caution. Direct contact may result in severe irritation of the skin and eyes, and it releases toxic vapours when heated. When handling this compound, it is imperative to utilize appropriate personal protective equipment (PPE), such as a lab coat, eyewear, and mittens. In addition, TMSOTf should be stored in a dry, cold location, far from combustible substances and ignition sources.

In conclusion,

Trimethylsilyl trifluoromethanesulfonate, by virtue of its electrophilic solid state and adaptability to diverse transformations, is an invaluable reagent in organic synthesis. Notwithstanding its reactivity, due diligence in handling and adherence to appropriate safety protocols enable chemists to exploit its synthetic capabilities efficiently. With the ongoing investigation of novel synthetic methodologies, TMSOTf will probably continue to be a significant entity in organic chemistry.

 

anap189
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Posts: 304
Jun 02nd, 2024 at 06:48

Ótimo conteúdo, gostei bastante. Avaliador premiado.

Muito obrigado, ajudou bastante. Avaliador premiado funciona.

 

anap189
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Posts: 304
Jun 02nd, 2024 at 06:49

Ótimo conteúdo, gostei bastante. Avaliador premiado.

 Muito obrigado, ajudou bastante. Avaliador premiado funciona.

 

CallumMason
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Posts: 6
Jun 03rd, 2024 at 05:55

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anap189
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Posts: 304
Jun 03rd, 2024 at 20:08

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bastana18
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