Tadalista 40 mg for erectile dysfunction, I would not recommend it for older men—or for younger men—without medical supervision. Age by itself does not require a tadalafil dose reduction; men over 65 can use tadalafil when medically appropriate. D DailyMed +1 However, for ED, the usual as-needed starting dose is 10 mg, with an increase to 20 mg if needed. 20 mg once daily is the usual maximum Tadalista 40 mg dose. D DailyMed 40 mg is not a standard ED dose. Tadalafil 40 mg is used for pulmonary arterial hypertension, which is a different condition and dosing regimen. D DailyMed Older adults may have greater sensitivity to tadalafil, and kidney/liver function and other medicines become particularly important. D DailyMed So, for an older man with ED, 10–20 mg is generally the range to discuss with a doctor rather than 40 mg. If you tell me the man's age (e.g., 60, 70, 80) and whether he takes blood-pressure, heart, prostate, or other medicines, I can explain the relevant safety considerations.