Duratia 60 mg contains dapoxetine as its active ingredient, and it is primarily used to treat premature ejaculation (PE) in men. When considering whether Duratia 60 mg interacts with other medications, it's essential to focus on potential drug interactions, especially those involving drugs that affect serotonin levels or liver enzymes.
Here are some classes of medications and specific drugs that may interact with Duratia 60 mg:
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Selective Serotonin Reuptake Inhibitors (SSRIs): Dapoxetine, the active ingredient in Duratia 60 mg, is a selective serotonin reuptake inhibitor (SSRI). Using Duratia 60 mg concurrently with other SSRIs or related medications can increase the risk of serotonin syndrome, a potentially serious condition characterized by symptoms such as confusion, agitation, rapid heartbeat, and high blood pressure.
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Monoamine Oxidase Inhibitors (MAOIs): MAOIs are another class of antidepressant medications that can interact with Duratia 60 mg. Concurrent use of MAOIs and dapoxetine can lead to an increased risk of serotonin syndrome.
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Thioridazine: Thioridazine, an antipsychotic medication, is contraindicated for use with Duratia 60 mg due to the potential for serious drug interactions, including QT prolongation and torsades de pointes (a type of irregular heart rhythm).
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CYP3A4 Inhibitors: Drugs that inhibit the CYP3A4 enzyme, such as ketoconazole, ritonavir, and clarithromycin, can increase the exposure to dapoxetine and may lead to an increased risk of adverse effects.
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CYP2D6 Inhibitors: Medications that inhibit the CYP2D6 enzyme, such as fluoxetine and paroxetine, can increase the exposure to dapoxetine and may lead to an increased risk of adverse effects.
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Alcohol: Drinking alcohol while taking Duratia 60 mg may increase the risk of side effects such as dizziness, drowsiness, and impaired judgment. It's generally recommended to avoid alcohol consumption while using this medication.
It's crucial to inform your healthcare provider about all medications you are currently taking, including prescription drugs, over-the-counter medications, herbal supplements, and recreational drugs, before starting Duratia 60 mg. Your doctor can assess the potential for drug interactions and adjust your treatment plan accordingly to ensure your safety and effectiveness of the medication.