Penegra 50 mg, which contains Sildenafil Citrate, can occasionally cause skin rashes as a side effect, though it's not very common. When it does occur, it is usually a mild allergic or sensitivity reaction to either the active ingredient or one of the inactive components in the tablet. Skin rash may develop shortly after taking the dose, typically within a few hours. This can present as: Itchy patches Red or raised spots Mild skin irritation These usually appear on the arms, chest, neck, or face and go away on their own once the drug wears off (within 4–6 hours). 2. As an Allergic Reaction Though rare, Sildenafil can trigger an allergic reaction, which may cause: Widespread hives (urticaria) Swelling of the face, lips, or throat (angioedema) Difficulty  Penegra 50 mg (a medical emergency) This usually happens within minutes to an hour after taking the drug and requires immediate medical attention. 3. Due to Drug Interactions or Medical Conditions People with sensitive skin, a history of drug allergies, or who are taking other medications (especially antibiotics or anti-inflammatories) may be more likely to develop a rash when taking Penegra. The rash is accompanied by swelling, itching, or shortness of breath You develop blisters, peeling skin, or fever (could be signs of serious reactions like Stevens-Johnson Syndrome — extremely rare but dangerous) The rash spreads rapidly or becomes painful or inflamed Stop taking the medication until you consult your doctor. Use over-the-counter antihistamines like cetirizine (if not contraindicated). Apply a mild hydrocortisone cream if approved by a healthcare provider. Severe rash or allergic signs: Stop the drug immediately Go to the emergency room or call emergency services If you're sensitive to Sildenafil (Penegra), your doctor may recommend: Tadalafil (Cialis) – longer-acting but different mechanism Vardenafil (Levitra) or Avanafil (Stendra) – other PDE5 inhibitors that may be better tolerated