Cenforce 25 mg contains sildenafil citrate, which is a PDE-5 inhibitor used to treat erectile dysfunction. About Grapefruit Juice Interaction: Grapefruit juice can interfere with the enzymes (mainly CYP3A4) that metabolize sildenafil in your body. Drinking grapefruit juice while taking sildenafil can increase the levels of the medication in your bloodstream, potentially leading to stronger effects and more side effects Cenforce 25 mg headache, flushing, dizziness, or low blood pressure. Safety Advice: It’s generally not recommended to take sildenafil (including Cenforce 25 mg) with grapefruit juice because of this interaction. If you want to drink grapefruit juice, it’s best to discuss with your doctor or pharmacist first, as they can give personalized advice based on your health condition and other medications.