Vigora Oral Jelly contains sildenafil, a PDE-5 inhibitor used for erectile dysfunction (ED). While it can help many men with ED, some people should avoid it or use it only under a doctor’s supervision because of possible health risks. People who should avoid Vigora Oral Jelly Men taking nitrate medicines Avoid Vigora Oral Jelly if you use nitrates for chest pain (such as nitroglycerin), because the combination can cause a dangerous drop in blood pressure. People with serious heart problems Men with unstable heart disease, recent heart attack, recent stroke, or those advised to avoid sexual activity due to heart risks should seek medical advice before using Vigora Oral Jelly . People with very low blood pressure Sildenafil can further lower blood pressure, so those with significant hypotension should avoid it unless cleared by a doctor. Those allergic to sildenafil or its ingredients Anyone with a known allergy to sildenafil should not take Vigora Oral Jelly. Men using certain pulmonary hypertension medicines Combining sildenafil with medicines such as riociguat may cause unsafe blood pressure changes. People with certain eye conditions Men with rare inherited eye disorders such as retinitis pigmentosa should discuss risks with a healthcare professional before use.