Zenegra 100 mg contains sildenafil citrate, a PDE5 inhibitor used for erectile dysfunction. Its safety in patients with liver problems depends on the severity of liver impairment. Here’s a detailed explanation: How liver function affects sildenafil Sildenafil is metabolized in the liver, mainly by CYP3A4 enzymes. If the liver is not working properly, the drug can accumulate, increasing the risk of side effects such as: Headache, flushing, dizziness Low blood pressure Irregular heartbeat Rare but serious: priapism or vision Zenegra 100 mg Guidelines for liver patients Mild to moderate liver impairment Sildenafil can usually be used, but doctors recommend starting at a lower dose (25–50 mg instead of 100 mg) to reduce side effects. Close monitoring is advised. Severe liver impairment Sildenafil, including Zenegra 100 mg, is usually not recommended because the risk of adverse effects is high. Medical supervision Liver patients should never self-medicate with 100 mg. A doctor may adjust the dose or suggest a lower-dose alternative, depending on liver enzyme tests and overall health. Interactions Be cautious with other medications metabolized by the liver (e.g., antifungals, certain antibiotics, or HIV meds), which can increase sildenafil levels.