Zenegra 50 mg does not usually require daily use. It contains sildenafil citrate, a medicine used to treat erectile dysfunction (ED). How often should you take Zenegra 50 mg? When needed: It is generally taken about 30–60 minutes before sexual activity. Daily use: It is not usually taken every day unless a doctor gives you specific instructions. Frequency limit: Do not take more than one dose in 24 hours. Duration: Its effects typically last around 4 hours, although this varies. Sexual stimulation: Is necessary for the medicine to work. Zenegra 50 mg it safe for regular use? Sildenafil can be used over the long term by some people when prescribed appropriately. However, if you have diabetes, heart disease, or take blood-pressure medicines, consult your doctor before using it. Never combine Zenegra with other erectile dysfunction medicines, such as Manforce, Viagra, Fildena or Tazzle. Do not take sildenafil with nitrate medicines or recreational poppers. One question: Do you want to use Zenegra 50 mg only when having sex, or are you considering taking .