Vigora 50 mg (sildenafil) can be taken with some antibiotics, but not all antibiotics are interchangeable in this regard. Sildenafil can interact with antibiotics such as erythromycin and clarithromycin, which can increase sildenafil levels and side effects. Rifampicin can have the opposite Vigora 50 mg  and reduce sildenafil levels. N nhs.uk +1 For example, azithromycin has not shown a clinically significant effect on sildenafil levels in a study, although your individual situation can differ. M Medicines.org.uk Tell me the exact antibiotic name and dose you're taking (for example, azithromycin 500 mg or amoxicillin 500 mg), and I can check whether it is compatible with Vigora 50 mg.