Avana 100 mg (avanafil) must NOT be taken with nitrates. Both medicines affect blood vessels. Together, they can cause a sudden, severe drop in blood pressure, potentially leading to: Fainting or collapse. Severe dizziness. Heart attack or stroke. Medicines that must not be combined with Avana 100 mg Sorbitrate (isosorbide dinitrate). Nitroglycerin (GTN). Isosorbide mononitrate. Angised. Other nitrate Avana 100 mg , including recreational nitrites ("poppers"). AVANAFIL tablet +1 If you have taken Avana 100 mg: Do not take nitroglycerin or other nitrates. If you develop chest pain, seek emergency medical help and tell the medical team when you took avanafil. Do not self-administer nitrates. The prescribing information says that even in a life-threatening emergency, nitrates should only be considered at least 12 hours after avanafil, under close medical supervision. AVANAFIL tablet One important question Are you taking any of these heart medicines? Sorbitrate 5 mg Angised Nitrocontin Ecosprin Amlodipine I can help you assess the interaction and whether Avana 100 mg is appropriate to discuss with your cardiologist.