Vidalista 20 contains tadalafil, and tadalafil can be taken with or without food, so taking it on an empty stomach does not prevent it from working. For ED, tadalafil is Vidalista 20 as needed or as a lower-dose daily treatment, depending on the prescribed regimen. The 20 mg strength should be used only as directed by a healthcare professional. Also, tadalafil should not be taken with nitrate medicines, because the combination can cause a dangerous drop in blood pressure.