Manforce 100 mg (which contains sildenafil citrate, a PDE‑5 inhibitor for erectile dysfunction) should be discussed with a doctor. This is important because even a standard 100 mg dose can have risks for certain people or in certain situations. Before starting Manforce 100 mg You should consult a doctor if you have: Heart or cardiovascular conditions History of heart attack, stroke, or unstable angina Severe heart failure or irregular heart rhythms Low blood pressure   or uncontrolled high blood pressure Medications that may interact Nitrates (e.g., nitroglycerin, isosorbide mononitrate) Some alpha-blockers, certain antifungals or antivirals Blood pressure medications that can cause hypotension Kidney or liver disease Severe liver impairment or chronic kidney disease can affect drug metabolism Eye or hearing problems History of vision loss due to non-arteritic anterior ischemic optic neuropathy (NAION) Recent sudden hearing loss or tinnitus Other medical conditions Sickle cell Manforce 100 mg , leukemia, or multiple myeloma (higher priapism risk) Dehydration or significant electrolyte imbalances  During illness or acute medical conditions Acute chest pain or cardiovascular event — do not take until cleared by a doctor. Fever, infection, or severe illness — can increase risk of side effects. Recent surgery — particularly heart surgery or major abdominal/pelvic surgery. If side effects occur Seek medical advice immediately if you experience: Prolonged or painful erection lasting more than 4 hours (priapism) Sudden vision changes or loss Sudden hearing loss or ringing in ears Severe dizziness, fainting, or chest pain  Key Takeaway Even though Manforce 100 mg is commonly prescribed, it is not risk-free. Any pre-existing heart, blood pressure, kidney, liver, eye, or hearing condition — as well as use of interacting medications — requires a discussion with a doctor before use.