Tazzle 20 mg (tadalafil) can be taken with or without food. You do not need an empty stomach for it to work. If you prefer taking it on an empty stomach: Take it with water. You can take it approximately 30–60 minutes before sexual activity. It may take up to 2 hours to reach its full effect. Its  Tazzle 20 Mg can last up to 36 hours. Sexual stimulation is still necessary. Important precautions Do not take more than one 20 mg tablet in 24 hours. Do not combine it with Tadarise, Fildena, Penegra or Manforce. Never combine it with nitrate medicines. Tadalafil 20 mg should be used under medical guidance. One question Are you planning to take Tazzle 20 mg for the first time, or have you taken tadalafil before?