Vilitra 20 mg contains Vardenafil 20 mg, a PDE5 inhibitor, and is used to treat erectile dysfunction (ED) in men. It works by increasing blood flow to the penis during sexual activity, helping men achieve and maintain an erection. Why Vilitra 20 mg Is Not Safe with Nitrates: Nitrates (such as nitroglycerin, isosorbide dinitrate, or isosorbide mononitrate) are medications typically used to treat chest pain (angina), heart failure, or high blood pressure. They work by relaxing blood vessels and improving blood flow, particularly to the heart. When Vilitra 20 mg (or other PDE5 inhibitors like Viagra or Cialis) is taken with nitrates, it can cause a severe and dangerous drop in blood pressure. Here’s why: How PDE5 Inhibitors (like Vilitra) and Nitrates Affect Blood Pressure:  Vilitra 20 mg  works by relaxing blood vessels in the penis, which helps increase blood flow to achieve and maintain an erection. It also has a general vasodilatory effect, meaning it relaxes and dilates blood vessels throughout the body, including the arteries that supply blood to the heart. Nitrates, when taken for chest pain or heart conditions, also relax and dilate blood vessels, which lowers blood pressure. This is helpful for relieving chest pain by improving blood flow to the heart. The Dangerous Interaction: When Vilitra 20 mg is taken along with nitrate medications, the combined vasodilation effect can lead to a significant drop in blood pressure.