Cenforce 25 mg contains sildenafil, a medicine used to treat erectile dysfunction. It may be safe for some people who take blood pressure medicine, but its safety depends on which blood pressure medicine you use, your blood pressure level, and your overall health. Sildenafil can lower blood pressure, so taking it with certain medicines may cause dizziness, weakness, fainting, or a sudden drop in blood pressure. Cenforce 25 mg : Never combine sildenafil with medicines such as nitroglycerin or isosorbide, as this can cause a dangerous fall in blood pressure. Alpha-blockers: Medicines such as doxazosin and prazosin may increase the risk of low blood pressure. Common BP medicines: Amlodipine, losartan, and many other blood pressure medicines may sometimes be used with sildenafil under medical supervision, but caution is necessary. Heart conditions: Consult your doctor before using sildenafil if you have heart disease, chest pain, or uncontrolled blood pressure. Important: Do not take Cenforce 25 mg until a doctor or pharmacist has checked your exact medicines. Never stop your prescribed blood pressure medicine to take Cenforce.