Tadarise 40 mg contains tadalafil, and alcohol can increase some of its side effects. What can happen Both tadalafil and alcohol widen blood vessels. Taking them together—especially with substantial alcohol consumption—can lower your blood pressure more than either alone. This can cause: Dizziness or light-headedness, particularly when standing Headache Flushing/warmth Faster heartbeat Fainting in more severe cases D DailyMed +1 The official prescribing information specifically warns that around Tadarise 40 mg  alcohol units with tadalafil increases the risk of these blood-pressure-related effects. D DailyMed One important issue with 40 mg For erectile dysfunction, tadalafil is normally used at 10–20 mg as needed. A 40 mg dose is higher than the usual ED dose, so combining Tadarise 40 mg with alcohol is particularly unwise without medical supervision. Given that you've previously asked about dizziness and headaches with ED medicines, alcohol could make those effects more noticeable. If you've already taken Tadarise 40 mg and alcohol and you're currently very dizzy, fainting, having chest pain, or having trouble breathing, seek urgent medical attention.