Zhewitra 10 mg contains Vardenafil, a PDE-5 inhibitor used for treating erectile dysfunction (ED). Alcohol can interact with it in several important ways: 1. Reduced Effectiveness Alcohol, especially in large amounts, can impair erectile function on its own. Even though Zhewitra works to increase blood flow to the penis, drinking heavily may reduce its effectiveness, making it harder to achieve or maintain an erection. 2. Increased Side Effects Both alcohol and Vardenafil can lower blood pressure. Combined, this can lead to: Dizziness or lightheadedness Fainting Rapid heartbeat Other side effects like headache, flushing, or nausea may also be more pronounced. 3. Timing Matters A small amount of alcohol (like a glass of wine) may not completely prevent Zhewitra 10 mg from working, but binge drinking can significantly interfere with results. 4. Safety Concerns People with heart problems, low blood pressure, or on nitrates should avoid alcohol completely when taking Zhewitra. Excessive alcohol increases the risk of serious cardiovascular side effects.  For best results, take Zhewitra 10 mg on a relatively empty stomach and limit alcohol, especially hard liquor, before sexual activity. I can also make a quick chart showing safe alcohol limits with Zhewitra to make this very clear — that usually helps prevent mistakes.