Vriligy 60 mg contains dapoxetine, which is not an erectile dysfunction (ED) drug — it’s used for premature ejaculation. PharmEasy +2 DrRxPharmacy.com +2 Here’s what I found about its interactions, especially in relation to ED drugs: Potential Interactions of Vriligy (Dapoxetine) With Other Medications (Non-ED) Dapoxetine interacts with warfarin, which increases bleeding risk. goodrxmedicine.com +2 Genericbucket +2 It also interacts with tramadol, lithium, and some antipsychotics  Also, caution if you drink grapefruit juice; it can increase levels of dapoxetine. PharmEasy With ED Drugs (PDE‑5 Inhibitors) I did not find reliable sources that state a direct pharmacological contraindication between dapoxetine (Vriligy) and common ED drugs like sildenafil  Vriligy 60 mg dapoxetine itself. eu.kamagra.net.pl On the KiWiDrug site, it mentions that Vriligy (dapoxetine) can cause erectile dysfunction (or reduced libido) in some men, but this is a side‑effect of Vriligy, not an interaction with another ED drug. kiwidrug.com Interpretation / Practical Advice Not inherently contraindicated: There’s no blanket prohibition in the sources against using Vriligy (dapoxetine) with ED drugs. Use under medical supervision: Because of possible increases in PDE-5 inhibitor levels (in some cases) and blood‑pressure effects, combining with ED drugs should be done carefully and with a doctor’s guidance. Be careful with other risk‑increasing medicines: Especially with medicines like ritonavir (HIV therapy), or when using nitrates, SSRIs, etc. Report side effects: If you feel too dizzy, lightheaded, or get prolonged erection (“priapism”), you should stop and consult your doctor.