If Cenforce contains sildenafil, it can be safe for some people with stable heart disease, but it is not automatically safe for all heart patients. Sildenafil causes blood-vessel relaxation and can lower blood pressure temporarily. D DailyMed +1 Do NOT take it if you use Nitroglycerin/GTN, isosorbide mononitrate, or isosorbide dinitrate (nitrate heart medicines). The combination can cause a dangerous fall in Cenforce pressure. D DailyMed Riociguat, unless specifically managed by your doctor. D DailyMed Extra caution is needed if you have unstable angina, severe heart failure, very low/high blood pressure, or recently had a heart attack, stroke, or serious arrhythmia. D DailyMed If you tell me your age, the Cenforce strength (e.g., 50 or 100 mg), your heart condition, and the names of your heart/BP medicines, I can check the combination more specifically.