Tadarise Pro 40 mg (which contains the active ingredient Tadalafil, a PDE‑5 inhibitor) at the same time as nitrate medications (used for chest pain/angina) because the combination can cause a dangerous drop in blood pressure. Why this matters Tadalafil enhances the effect of vasodilation (widening of blood vessels). cheapmedicineshop.com +3 burelpharma.com +3 openaccessjournals.com +3 Nitrates also dilate blood vessels. When combined with a PDE‑5 inhibitor, the risk of a marked drop in blood pressure is significantly elevated. fordailymedicine +2 FDA Access Data +2 According to prescribing information for tadalafil: “The use of tadalafil in patients taking any form of nitrates is contraindicated.” burelpharma.com Tadarise Pro 40 mg if tadalafil has been taken, nitrates should be avoided for at least 48 hours after use, and only used under close monitoring in emergencies. FDA Access Data +1 What you should do If you are on a nitrate medication (for example, nitroglycerin, isosorbide mononitrate, isosorbide dinitrate, or other nitrate forms) do not take Tadarise Pro 40 mg without talking to your doctor. If you take Tadarise Pro, inform your cardiologist/doctor that you are using it—so that if you ever need nitrates, it’s known and can be managed. Always disclose all your medications (heart, blood pressure, ED, etc.) to your healthcare provider before starting ED treatments like tadalafil. If you experience chest pain (“angina”) and have recently taken Tadarise Pro, tell the emergency team about this drug use—because standard treatment with nitrates may be more risky.