Malegra DXT Plus combines sildenafil citrate (a PDE5 inhibitor) with duloxetine to help with erectile dysfunction (ED) and premature ejaculation. Sildenafil works by relaxing blood vessels and increasing blood flow to the penis, while duloxetine helps with ejaculatory control and psychological aspects of sexual performance.

For men with benign prostatic hyperplasia (BPH) — an enlarged prostate causing urinary symptoms — sildenafil itself is not officially approved as a treatment for prostate enlargement, and evidence is mixed or limited. Some clinical research has explored whether sildenafil can improve lower urinary tract symptoms (LUTS) associated with BPH, often alongside standard BPH medications like alpha‑blockers, but results are inconsistent.

In one clinical trial, adding Malegra DXT Plus to an alpha‑blocker improved urinary symptoms and erectile function more than the alpha‑blocker alone in men with BPH and ED. However, this doesn’t mean sildenafil directly treats prostate enlargement — its main role remains improving erectile function. Evidence reviews note that while PDE5 inhibitors might help smooth muscle relaxation in lower urinary tract tissues, they aren’t first‑line BPH therapy and aren’t licensed for that indication in many regions.

Important: Always consult a healthcare professional before using Malegra DXT Plus if you have prostate issues, as interactions with other medications and your overall health must be evaluated.