Vilitra contains vardenafil, a PDE5 inhibitor used for erectile dysfunction. Its interaction with nitrates is potentially dangerous and must be understood carefully. How the Interaction Works Both vardenafil (in Vilitra) and nitrates (such as nitroglycerin, isosorbide dinitrate) relax blood vessels. When taken together, this combination can cause a severe and sudden drop in blood pressure. Symptoms of this dangerous drop include: Dizziness or fainting Rapid or irregular heartbeat Chest pain Shock in extreme Vilitra Even a small amount of nitrate taken while on Vilitra can trigger this reaction, so it is contraindicated. Safety Guidelines Never take Vilitra with nitrates in any form (oral, sublingual, patch, spray). If you have taken nitrates recently, wait at least 24–48 hours before taking Vilitra (exact timing should be confirmed by a doctor). Emergency situations: If chest pain occurs after taking Vilitra, do not take nitrates—seek immediate medical attention. Why This Matters This interaction is life-threatening, not just uncomfortable. Many deaths and hospitalizations have been reported when PDE5 inhibitors and nitrates are combined. I can also make a simple chart showing Vilitra interactions with heart medications and safe alternatives if you want. This is useful for avoiding dangerous combinations.