Cenforce 100 mg contains sildenafil 100 mg, taking one dose on a weekend can be consistent with the usual “as needed” use, provided it is safe for you and has been prescribed/recommended for you. Sildenafil can be taken as needed, but the maximum recommended frequency is once in 24 hours. A few important points: 100 mg is the maximum recommended single dose; 50 mg is the usual starting dose. Cenforce 100 mg take more than one dose in a day, even if the first dose doesn't work well. Never combine sildenafil with nitrate medicines such as nitroglycerin or isosorbide, because blood pressure can fall dangerously. It can also interact with certain blood-pressure medicines, alpha-blockers, and some antibiotics/antifungals. If you have significant heart disease or have been told sexual activity is unsafe for you, you should get medical advice before using it. If you tell me your age and the other medicines you take, I can tell you whether Cenforce 100 mg every weekend is likely to be appropriate and whether 50 mg might be safer.