Avana 200 mg contains Avanafil, a medication used to treat erectile dysfunction (ED) by increasing blood flow to the penis. Like other ED medications, Avanafil can interact with certain drugs, leading to potential side effects or reduced effectiveness. Some common drug interactions include:

1. Nitrates (e.g., Nitroglycerin): Nitrate medications, often prescribed for chest pain (angina) or heart conditions, can interact dangerously with Avanafil. The combination can cause a significant drop in blood pressure, leading to dizziness, fainting, or even a heart attack or stroke. You should never take Avanafil with nitrates.

2. Alpha-blockers (e.g., Doxazosin, Tamsulosin): These are used to treat high blood pressure or symptoms of an enlarged prostate. When taken with Avana 200 mg, they can lower blood pressure too much, causing dizziness, lightheadedness, or fainting. Your doctor may adjust the doses or recommend a safer timing for use.

3. Antifungals (e.g., Ketoconazole, Itraconazole): Certain antifungal medications can increase the levels of Avanafil in the blood, potentially raising the risk of side effects like headaches, flushing, or dizziness.

4. Antibiotics (e.g., Erythromycin, Clarithromycin): These antibiotics can also raise Avanafil's blood levels, increasing the likelihood of side effects. If you are prescribed these antibiotics, your doctor may adjust the Avanafil dosage or timing.

5. HIV Protease Inhibitors (e.g., Ritonavir, Lopinavir): These medications can interfere with Avanafil metabolism, leading to higher drug levels and an increased risk of side effects.

6. Rifampin (an antibiotic): Rifampin can lower the effectiveness of Avanafil by increasing its metabolism, reducing its effectiveness in treating ED.

7. Other ED Medications: Combining Avanafil with other PDE5 inhibitors (like Sildenafil, Tadalafil, or Vardenafil) can increase the risk of side effects like low blood pressure, dizziness, and prolonged erections (priapism).

8. Grapefruit and Grapefruit Juice: Grapefruit can affect the enzymes that metabolize Avanafil, potentially increasing its levels in the body and leading to more side effects.

It's important to consult with your healthcare provider before taking Avanafil to ensure that no dangerous interactions occur with your current medications or medical conditions. They can help adjust dosages or suggest alternatives if needed.