Iverheal 12 mg contains ivermectin, an antiparasitic medication used to treat certain infections. When taking Iverheal, it’s generally advised to avoid consuming grapefruit juice due to the potential for interaction that could affect the medication’s effectiveness and safety. Why Grapefruit Juice Should Be Avoided with Iverheal 12 mg Inhibition of Enzyme CYP3A4 Grapefruit juice contains compounds (like furanocoumarins) that inhibit the enzyme CYP3A4, which is responsible for metabolizing many drugs, including ivermectin. By inhibiting CYP3A4, grapefruit juice can slow down the breakdown of ivermectin in the liver, causing it to stay in the bloodstream longer than intended. This can lead to an increased risk of side effects due to higher-than-expected drug levels. Increased Risk of Side Effects Higher levels of ivermectin in the body can increase the likelihood of experiencing adverse effects, such as dizziness, nausea, headache, or even more serious neurological effects in some cases. Overaccumulation of ivermectin can potentially lead to toxicity, which may cause severe reactions such as seizures, confusion, or coordination issues. Altered Effectiveness of the Medication Grapefruit juice might not only increase the side effects but also alter the intended therapeutic effect of ivermectin. If the drug levels are too high, the body might respond unpredictably, potentially compromising its effectiveness against parasites or leading to erratic drug behavior. Other Considerations Timing Does Not Help: Even if you don’t take grapefruit juice at the exact time as Iverheal, it can still affect the drug's metabolism. The effects of grapefruit on the liver enzyme CYP3A4 can last for up to 24 hours, meaning the interaction risk is present throughout the day. Other Citrus Fruits: Some other citrus fruits, like Seville oranges, limes, and pomelos, may also have similar effects on CYP3A4 and should be avoided as well. Conclusion To avoid potential side effects and ensure the effectiveness of Iverheal 12 mg, it’s best to avoid grapefruit juice and similar citrus products during the course of treatment. If you have any questions about diet or drug interactions, consulting a healthcare provider is always recommended.