Malegra DXT is a combination medication used to treat erectile dysfunction (ED) and premature ejaculation (PE) in men. It contains two active ingredients: sildenafil citrate (100 mg), a PDE5 inhibitor for ED, and duloxetine (30 mg), a serotonin-norepinephrine reuptake inhibitor (SNRI) used to delay ejaculation. Because it contains two powerful compounds, Malegra DXT can influence the effectiveness and safety of other medications.

Sildenafil may interact with drugs such as nitrates (used for chest pain), alpha-blockers (used for blood pressure or prostate issues), and some antifungal or antibiotic medications, leading to a dangerous drop in blood pressure or other adverse effects. Duloxetine may affect or be affected by other antidepressants, painkillers, or blood thinners, increasing the risk of serotonin syndrome, bleeding, or side effects like dizziness and drowsiness.

Taking Malegra DXT with alcohol or CNS depressants may enhance sedative effects, impacting mental alertness. Because of these potential interactions, it is crucial to consult a healthcare provider before using Malegra DXT, especially if you are on multiple medications or have underlying health conditions. Always use it under medical supervision to ensure safety.