Extra Super Vidalista contains two active ingredients, Tadalafil and Dapoxetine, which work together to treat both erectile dysfunction (ED) and premature ejaculation (PE). However, certain individuals may experience contraindications with Extra Super Vidalista, especially those with underlying health conditions or who are taking specific medications. Here are some groups who should be cautious or avoid taking this medication: 1. Individuals with Heart Conditions People with severe heart disease, recent history of heart attack (within the last 6 months), unstable angina, or arrhythmias should avoid this medication. Extra Super Vidalista , a PDE5 inhibitor, can cause changes in blood pressure that might stress the heart. Those taking nitrates for heart conditions (such as nitroglycerin) should not take Extra Super Vidalista, as the combination of nitrates and Tadalafil can cause a dangerous drop in blood pressure. 2. Those with Liver or Kidney Issues Severe liver or kidney disease may impair the body’s ability to process Tadalafil and Dapoxetine, leading to potential toxicity and increased risk of side effects. Individuals with mild-to-moderate liver or kidney disease may still be able to take Extra Super Vidalista but should do so only under medical supervision with adjusted dosing. 3. People Taking Medications that Interact with Tadalafil or Dapoxetine Alpha-blockers (used to treat high blood pressure or prostate conditions) may interact with Tadalafil, causing excessive drops in blood pressure. Antidepressants, especially SSRIs, MAO inhibitors, and certain antipsychotics, can interact with Dapoxetine, potentially leading to serotonin syndrome, a severe condition caused by excessive serotonin levels. Medications that affect liver enzymes, such as antifungals (e.g., ketoconazole) and antibiotics (e.g., erythromycin), may interfere with the metabolism of Extra Super Vidalista, increasing the risk of side effects. 4. Men with a History of Eye Conditions Individuals with retinitis pigmentosa or a history of non-arteritic anterior ischemic optic neuropathy (NAION) may be at higher risk for vision issues when taking Tadalafil. 5. People with Blood Pressure Issues Those with hypotension (low blood pressure) or uncontrolled high blood pressure should avoid this medication. Tadalafil can cause drops in blood pressure, potentially leading to dizziness, fainting, or, in severe cases, stroke. 6. Individuals with Certain Mental Health Disorders Since Extra Super Vidalista includes Dapoxetine, a drug with effects on mood, people with a history of bipolar disorder, severe depression, or suicidal thoughts should use caution and consult a healthcare provider, as Dapoxetine may worsen these conditions. 7. Men Over the Age of 65 Older adults may have slower metabolism and are often more susceptible to the side effects of medications like Tadalafil and Dapoxetine. Dosage adjustments or alternative treatments may be considered.