Vidalista 60 (or any other medication containing Tadalafil, such as Vidalista 20 or Cialis) with nitrates can cause severe health risks, primarily due to the significant drop in blood pressure that may occur. Here's why it’s dangerous: Blood Pressure Lowering Effect: Vidalista 60 (Tadalafil) works by inhibiting the PDE5 enzyme, which leads to increased blood flow to the penis during sexual arousal. However, this process also causes vasodilation (widening of blood vessels) and can lower blood pressure. Nitrates (such as nitroglycerin, commonly used for treating angina or chest pain) also have a blood pressure-lowering effect. They work by relaxing and dilating blood vessels to improve blood flow, especially to the heart. When both medications are taken together, the combined vasodilation effect can lead to severe hypotension (abnormally low blood pressure). This can result in dangerous side effects, including: Dizziness or lightheadedness Fainting Heart attack Stroke Death (in extreme cases) Sudden Drop in Blood Pressure: The combined effects of Tadalafil and nitrates can lead to a dramatic and sudden drop in blood pressure, which can be life-threatening. This is especially risky if you already have a history of heart Vidalista 60 or if you are in a situation where your blood pressure needs to be regulated carefully. Warning: It is absolutely contraindicated to take nitrates (e.g., nitroglycerin) with any PDE5 inhibitor like Tadalafil (Vidalista 60) due to the risk of severe hypotension. If you are currently taking nitrates for chest pain or any other condition, you should not take Vidalista 60, Cialis, or any similar medication containing Tadalafil. What to Do if You Accidentally Take Both: Seek immediate medical attention if you take Vidalista 60 and a nitrate (or any medication containing nitrates) together. Medical professionals can monitor your condition and take steps to stabilize your blood pressure if needed. How to Avoid the Risk: Consult your doctor: If you're being prescribed Vidalista 60 for erectile dysfunction and you are also taking nitrate medications, inform your doctor. They can help you find an alternative treatment that does not pose such risks. Do not mix medications: Never combine PDE5 inhibitors like Tadalafil with nitrate-based medications unless explicitly instructed by your doctor. Other Considerations: If you’re prescribed nitrates for a condition like angina or heart disease, it is very important to discuss all your medications with your doctor to avoid dangerous interactions with medications like Vidalista 60.