Cenforce 25 mg contains sildenafil citrate, a medicine commonly used to treat erectile dysfunction (difficulty getting or maintaining an erection). It can interact with several medicines, potentially causing a dangerous drop in blood pressure or increasing side effects. The most important thing is to check your other medicines with a doctor or pharmacist before taking Cenforce 25 mg. Access Data +1 1. Medicines that can interact with Cenforce 25 mg Nitrates for chest pain — do not combine Examples: nitroglycerin (GTN), isosorbide mononitrate and isosorbide dinitrate. Combining these with sildenafil can cause a sudden, potentially life-threatening drop in blood pressure. Recreational nitrites known as “poppers” are also dangerous. Blood pressure and Cenforce 25 mg medicines Examples: amlodipine, doxazosin, tamsulosin and terazosin. These can increase the risk of low blood pressure, dizziness or fainting when combined with Cenforce. A clinician may need to adjust the treatment. Certain antibiotics and antifungals Examples: erythromycin, clarithromycin, ketoconazole and itraconazole. These can slow the breakdown of sildenafil, increasing its concentration in your body and the chance of side effects. HIV medicines Examples: ritonavir and some other HIV protease inhibitors. These can substantially increase sildenafil levels. For ritonavir, official sildenafil prescribing information limits the dose to no more than 25 mg in a 48-hour period; medical guidance is essential. Other erectile dysfunction or pulmonary hypertension medicines Examples: tadalafil, vardenafil and riociguat. Combining erectile dysfunction medicines can increase adverse effects. Riociguat must not be combined with sildenafil because of the risk of severe hypotension. Sources: FDA sildenafil prescribing information and NHS guidance. Access Data +2 2. What about alcohol, food and supplements? Alcohol: Drinking heavily can increase dizziness and lower blood pressure, and may make erections more difficult. Grapefruit or grapefruit juice: May increase sildenafil levels and side effects; it is best avoided. Herbal supplements: St John's wort can reduce sildenafil levels. Tell your pharmacist about all sexual-performance supplements and herbal products. Other medicines: Some seizure medicines, such as carbamazepine and phenytoin, can reduce sildenafil's effectiveness.