Vidalista 5 (tadalafil) should be avoided if you have certain medical conditions, particularly heart-related issues. Individuals with severe cardiovascular disorders such as unstable angina, recent heart attack (myocardial infarction), or stroke within the past six months should not take Vidalista 5mg. It can lower blood pressure significantly, especially when combined with nitrates often prescribed for chest pain, leading to dangerous cardiovascular effects. People with severe liver or kidney impairment should also avoid it unless prescribed under strict medical supervision, as the drug may not be properly metabolized or excreted. Additionally, those with retinitis pigmentosa, a rare eye condition, or individuals with known hypersensitivity to tadalafil or similar medications, should not use Vidalista 5. Always consult a doctor before starting this medication.