Cenforce D Extra Power is a combination medication used to treat erectile dysfunction (ED) and premature ejaculation (PE). It contains two active ingredients: Sildenafil Citrate (100 mg): A PDE5 inhibitor that helps improve blood flow to the penis, facilitating an erection in response to sexual arousal. Dapoxetine (60 mg): A selective serotonin reuptake inhibitor (SSRI), which helps delay ejaculation by increasing serotonin levels in the brain. Is Cenforce D Extra Power Safe for Long-Term Use? Cenforce D Extra Power can be safe for long-term use in many men with ED and PE, but there are several important considerations to keep in mind, particularly regarding Sildenafil and Dapoxetine, the active ingredients. Long-Term Safety Considerations: 1. Sildenafil (100 mg) – Long-Term Safety: Sildenafil Citrate, the active ingredient in Cenforce D Extra Power, is generally considered safe for long-term use in men with erectile dysfunction (ED), as long as there are no contraindications or serious side effects. Cenforce D Extra Power  use of Sildenafil in men with normal heart function has not been associated with long-term harm to the cardiovascular system, kidneys, or other organs when taken at the recommended doses. However, if you have underlying heart conditions, severe liver or kidney disease, or are taking nitrate medications (e.g., for chest pain), Sildenafil can cause adverse effects, including dangerously low blood pressure. Regular Monitoring: If you're using Sildenafil long-term, it is a good idea to have regular check-ups with your healthcare provider to monitor blood pressure, heart health, and overall wellbeing. 2. Dapoxetine (60 mg) – Long-Term Safety: Dapoxetine is a short-acting SSRI, specifically designed to treat premature ejaculation. While SSRIs are generally well-tolerated for long-term use in other conditions (e.g., depression, anxiety), Dapoxetine is not as commonly used for extended periods. In clinical studies, Dapoxetine has been shown to improve symptoms of premature ejaculation in the short term. However, the long-term safety of Dapoxetine for PE has not been as thoroughly studied as other SSRIs used for depression, so there are fewer data on its prolonged use. Side Effects of Dapoxetine: Some men may experience side effects such as nausea, dizziness, headache, fatigue, and diarrhea when using Dapoxetine. These side effects are usually temporary, but they could become bothersome with long-term use.