Cenforce 50 mg usually starts working within 30–60 minutes. It contains sildenafil citrate, which is used to treat erectile dysfunction (ED). How quickly does Cenforce 50 work? Onset: Usually 30–60 minutes after taking it. Duration: Around 4–6 hours, although this varies. Food: A heavy or high-fat Cenforce 50 mg  may delay its effect. Sexual stimulation: Required for it to help produce an erection. Is 50 mg enough? For many adults, 50 mg is a common starting dose. A higher dose is not necessarily more effective and may cause more side effects, so don't increase it without medical advice. Important: Never take Cenforce with nitrate medicines such as nitroglycerin or isosorbide. Seek emergency care for chest pain, sudden vision or hearing loss, or an erection lasting more than four hours. Are you asking because you want Cenforce to work faster, or because you're comparing it with Fildena or Vilitra?