Zenegra 50 mg contains sildenafil 50 mg, and it can be taken on an empty stomach or with food. A Apollo Pharmacy +1 If your goal is faster onset, taking it on an empty stomach is generally preferable. Sildenafil reaches peak blood levels in roughly 30–120 minutes (median ~60 minutes) when fasting. A high-fat meal can delay absorption by about 1 hour. M Medicines.org.uk Typical use: take 50 mg about Zenegra 50 mg  before sexual activity, with sexual stimulation required for it to work. Do not take more than once in 24 hours. D DailyMed Since you mentioned high blood pressure earlier: do not take sildenafil with nitrate medicines (such as nitroglycerin/isosorbide), because the combination can cause a dangerous drop in blood pressure.