Duratia 90 mg contains Tadalafil, and it is advised not to take it with grapefruit juice because: Why avoid grapefruit juice with Duratia 90 mg? Grapefruit juice contains compounds that inhibit the enzyme CYP3A4 in the liver and intestines. CYP3A4 is responsible for metabolizing (breaking down) Duratia 90 mg drugs, including Tadalafil. When grapefruit juice blocks CYP3A4, Tadalafil’s metabolism slows down, leading to higher levels of the drug in the bloodstream. This can increase the risk of side effects such as headache, dizziness, low blood pressure, and prolonged erections. Summary from your document: Grapefruit juice can significantly raise Tadalafil concentration, potentially leading to overdose-like effects. To ensure safe and effective use, avoid grapefruit or grapefruit-containing products while taking Duratia 90 mg.

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