Duratia 60 mg contains dapoxetine 60 mg, it is a short-acting medicine for premature ejaculation, not a medicine that keeps working all day. It is absorbed quickly, reaching peak blood levels at about 1–1.5 hours after taking it. P PubMed Central (PMC) +1 Its initial half-life is only about 1.4 hours, so the drug level falls relatively quickly. P PubMed Central (PMC) The terminal half-life is around 20–22 hours, Duratia 60 mg this does not mean its sexual effect lasts 20 hours. Blood levels are already below about 5% of peak by 24 hours. P PubMed Central (PMC) So, practically, Duratia 60 mg is intended for on-demand use around 1–3 hours before sexual activity, rather than for prolonged continuous effect. Also, 60 mg is the higher dapoxetine dose and can increase side effects such as nausea, dizziness, headache, and fainting. Avoid excessive alcohol, and don't take more than one dose in 24 hours. P PubMed Central (PMC) If you're asking because you want something that lasts longer for premature ejaculation, I can compare dapoxetine 30/60 mg with tadalafil or sildenafil and explain what each one actually does.