Tadalista 20 mg (which contains Tadalafil) generally does not work immediately after taking it. While Tadalafil is faster-acting compared to some other erectile dysfunction (ED) medications, it still takes some time to take effect. Here's a more detailed breakdown: How Long Does It Take for Tadalista 20 mg to Work? Onset of Action: Tadalista 20 mg typically starts to work within 30 to 60 minutes after taking it. However, this can vary depending on individual factors such as metabolism, overall health, and whether it is taken with food. Time to Full Effect: For Tadalista 20 mg to reach its maximum effect, it may take about 1 to 2 hours. This means you should plan to take the medication about 30 minutes to 1 hour before sexual activity for optimal results. Factors Tadalista 20 mg Can Affect the Onset: Food: Taking Tadalista 20 mg with a high-fat meal (like fried food or fatty meats) may slow down its absorption, delaying its effects. Ideally, it's best to take Tadalista on an empty stomach or after a light meal to ensure it works faster. Alcohol: Excessive alcohol consumption can delay the effectiveness of Tadalista 20 mg. While moderate drinking might not have a significant impact, heavy drinking can make it harder to achieve or maintain an erection, even if the medication is working. Other Medications: Certain medications can interact with Tadalista 20 mg and either enhance or inhibit its effects. For example, nitrate medications for chest pain should not be taken with Tadalista, as this combination can cause a dangerous drop in blood pressure.