Tadalista 40 mg (Tadalafil) should not be mixed with certain medications because dangerous interactions can occur. The main concerns are drugs that affect blood pressure or heart function. Here’s a detailed breakdown: 1. Nitrates Includes drugs like nitroglycerin, isosorbide mononitrate, and isosorbide dinitrate. Why: Combining with Tadalafil can cause a sudden, severe drop in blood pressure, which can be life-threatening. 2. Alpha-blockers Includes drugs like tamsulosin, doxazosin, alfuzosin (used for prostate enlargement or high blood pressure). Why: May lead to low blood pressure, dizziness, or fainting. 3. Other PDE5 inhibitors Tadalista 40 mg with sildenafil, vardenafil, avanafil can increase side effects without added benefit. 4. Certain HIV, antifungal, or antibiotic medications Drugs like ritonavir, ketoconazole, itraconazole, clarithromycin can increase Tadalafil levels, raising risk of headache, dizziness, or priapism. 5. Heart medications Especially those that affect blood pressure or heart rhythm. Careful consultation with a doctor is required.  Always consult a doctor before combining Tadalista 40 mg with any other prescription, over-the-counter, or herbal medication. If you want, I can make a quick reference table of “Safe vs Unsafe Combinations” for Tadalista 40 mg—it’s easier to memorize.