Cenforce 130 mg contains sildenafil citrate. Grapefruit can affect sildenafil metabolism because grapefruit compounds can inhibit the CYP3A4 enzyme in the intestine, which normally helps break down sildenafil. When the interaction is most relevant: If you consume grapefruit or grapefruit juice before taking Cenforce 130 mg, the effect may be stronger because less sildenafil is broken down. The enzyme Cenforce 130 mg can persist for many hours and sometimes up to a day or longer, so avoiding grapefruit on the same day as taking Cenforce 130 mg is a cautious approach. Large amounts of grapefruit or concentrated grapefruit juice are more likely to cause an interaction than a small occasional amount. Possible effects from increased sildenafil levels include: Stronger or longer-lasting effects Headache Flushing Dizziness Low blood pressure Fast heartbeat Vision changes Also note that Cenforce 130 mg is a higher-than-standard sildenafil dose (usual maximum recommended sildenafil dose is often 100 mg), so grapefruit-related increases in sildenafil exposure could be more concerning.