Vriligy 60 mg contains dapoxetine 60 mg, a short‑acting SSRI used for premature ejaculation (PE). Whether it “works the first time” depends on several factors. Let’s break it down carefully: 1. How Vriligy Works Dapoxetine increases serotonin in the nervous system, which helps delay ejaculation. It is taken 1–3 hours before sexual activity and is not meant for daily use. Its effectiveness depends on proper timing, sexual stimulation, and individual response. 2. First-Time Effectiveness Many men notice improvement the first time they take it, but this varies by individual. Some men may need 1–2 tries to experience full benefit, because psychological factors, stress, anxiety, or performance pressure can affect outcomes. Effectiveness may also depend on dose and body weight, metabolism, and whether taken with a heavy meal (which can slow absorption). 3. Important Tips Take 1–3 hours before sex. Avoid alcohol, which can reduce effectiveness and increase side effects like dizziness or drowsiness. Do not exceed one dose in 24 hours. Be aware of potential side effects: dizziness, headache, nausea, drowsiness, or blurred vision. Vriligy 60 mg can work the first time, but results vary. Some men notice immediate benefit, while others may need a few tries for the full effect. If you want, I can make a step-by-step guide on how to maximize first-time effectiveness of Vriligy 60 mg safely.