Malegra Oral Jelly can be dangerous in some situations, especially if not taken under medical guidance. Malegra Oral Jelly contains sildenafil citrate, a PDE5‑inhibitor used for erectile dysfunction. Like all active medicines, it can interact with certain drugs, foods, alcohol, and medical conditions, sometimes with serious consequences.  Serious Drug Interactions Some interactions can lead to dangerously low blood pressure, heart issues, or other serious effects: 1. Nitrate medicines Drugs for chest pain (nitroglycerin, isosorbide dinitrate, etc.) Combining these with sildenafil can cause a severe drop in blood pressure, fainting, heart attack, or stroke. Malegra Oral Jelly is one of the most dangerous interactions. 2. Alpha‑blockers and blood pressure drugs Medicines like amlodipine, metoprolol, some antihypertensives Can additionally lower blood pressure and lead to dizziness, fainting, or falls. 3. HIV protease inhibitors / CYP3A4 inhibitors Ritonavir, cobicistat, clarithromycin, ketoconazole, etc. These can increase sildenafil levels, raising the risk of side effects (e.g., headache, flushing, vision changes, hypotension). 4. Other erectile dysfunction drugs Stacking with other PDE5 inhibitors like tadalafil or vardenafil can amplify side effects.  ood and Lifestyle Interactions Alcohol: Can increase dizziness, lower blood pressure more than expected, and impair judgment. Grapefruit or grapefruit juice: May increase sildenafil levels, raising the chance of side effects.