Cenforce Professional contains sildenafil citrate combined with dapoxetine, targeting erectile dysfunction and premature ejaculation. Certain medical conditions can worsen or increase risks when using this medication. Here are the key conditions where caution or avoidance is essential: Heart Disease: People with recent heart attack, unstable angina, severe heart failure, or arrhythmias should avoid Cenforce Professional or use it only under strict medical supervision. Sildenafil affects blood vessels and blood pressure, which can strain a compromised heart. Low or High Blood Pressure: Uncontrolled hypertension or hypotension can be worsened by sildenafil’s blood vessel dilation effects, potentially causing dangerous drops in blood pressure or complications. Liver or Kidney Disease: Impaired liver or kidney function can alter how the drug is metabolized and cleared, increasing side effect risks and requiring dose adjustments. Nitrate Use: Taking nitrates (often prescribed for chest pain) with Cenforce Professional can cause a severe and potentially life-threatening drop in blood pressure. Certain Eye Conditions: People with retinitis pigmentosa or a history of non-arteritic anterior ischemic optic neuropathy (NAION) should avoid sildenafil, as it may worsen vision problems. Psychiatric Disorders: Dapoxetine, a serotonin reuptake inhibitor, can interact with other psychiatric medications or worsen certain mental health conditions like depression or anxiety. Stroke or Seizure History: Caution is advised because sildenafil and dapoxetine can potentially increase the risk of neurological side effects. Allergy to Ingredients: Any known allergy to sildenafil, dapoxetine, or other formulation components contraindicates use.