Penegra 50 mg (sildenafil) can happen because it widens blood vessels and increases blood flow, which can affect pressure in the head. When headaches usually occur Most people who get headaches experience them: 1. 30 minutes to 2 hours after taking the tablet This is when the drug starts working strongly Blood vessels expand → pressure changes in head → headache may begin 2. During peak effect (1–3 hours after dose) This is the most common time for moderate to strong headache Sexual activity can make it worse due to physical exertion 3. Within the first few uses Side effects like headache are more common when you first start Penegra 50 mg people notice it becomes milder over time What increases the chance of headache You’re more likely to get it if: You take a higher dose than needed You drink alcohol You are dehydrated You take it on an empty stomach with low hydration You already have a tendency for migraines or sinus headaches How long it lasts Usually 1–4 hours Goes away as the medicine wears off When to be careful Seek medical advice if: Headache is very severe or sudden It comes with vision changes, chest pain, or dizziness It lasts more than 6–8 hours If you want, I can also tell you how to reduce headaches while still keeping the medicine effective.