Tadalista 60 mg, containing Tadalafil, is metabolized in the body through a well-defined pharmacokinetic pathway that influences its onset, duration, and overall effectiveness. Metabolic Pathway of Tadalafil Absorption: After oral administration, Tadalafil is rapidly absorbed, with peak plasma concentrations typically reached within 2 hours. Its absorption is not significantly affected by food intake, allowing for flexible dosing. NCBI Distribution: The drug is widely distributed throughout the body, with an Tadalista 60 mg volume of distribution ranging from 63 to 77 liters. Approximately 94% of Tadalafil in plasma is bound to proteins such as albumin and α-1 acid glycoprotein. Medicine.com Metabolism: Tadalafil is primarily metabolized in the liver by the CYP3A4 enzyme. This metabolic process produces several metabolites, with the major one being methylcatechol glucuronide, which is pharmacologically inactive. NCBI Excretion: The drug and its metabolites are predominantly excreted via the feces (approximately 61%), with a smaller amount eliminated through the urine (around 36%). NCBI ⏱️ Half-Life and Duration of Action Tadalafil has a terminal half-life of approximately 17.5 hours, which supports its prolonged duration of action, making it suitable for once-daily dosing in chronic conditions.  Considerations for Special Populations Renal Impairment: In patients with compromised kidney function, the clearance of Tadalafil may be reduced, leading to increased plasma concentrations. Medicine.com Hepatic Impairment: Individuals with liver dysfunction may experience altered metabolism of Tadalafil, necessitating dose adjustments. Medicine.com