Penegra 50 mg contains sildenafil, and the dose is usually increased to 100 mg only when 50 mg is not giving enough benefit and is well tolerated. The increase should be discussed with a doctor rather than done routinely. A doctor may consider increasing from 50 mg to 100 mg if: You have taken 50 mg correctly on several occasions (usually about 1 hour before sexual activity) and still do not get a satisfactory erection. You have no significant side effects from 50 mg (such as severe headache, dizziness, flushing, low blood Penegra 50 mg , or vision changes). You do not have conditions or medicines that make higher doses risky. Do not increase the dose if you: Take nitrate medicines for chest pain or use riociguat Have unstable heart disease or have been advised to avoid sexual activity Have had serious side effects from sildenafil before The usual maximum recommended sildenafil dose is 100 mg once in 24 hours; taking more does not usually improve results and can increase side effects. If you tell me your age, how long you have used Penegra 50 mg, whether it works partially or not at all, and any BP/heart medicines, I can help you judge whether a dose review makes sense.