Cenforce contains sildenafil, a medicine used to treat erectile dysfunction (ED). It can generally be taken with or without food, but what you eat can affect how quickly it works. How to take Cenforce with food Best timing: Taking it on an empty stomach or after a light meal may help it work sooner. Heavy or fatty meals: Foods such as fried foods, creamy curries, and high-fat meals may delay the onset of Cenforce . Water: Swallow the tablet with water, following your prescription. Timing: Sildenafil is usually taken about 30–60 minutes before sexual activity. Frequency: Do not take more than one dose in 24 hours unless your doctor specifically instructs you otherwise. Important safety precautions Do not take Cenforce with nitrate medicines such as nitroglycerin. Do not combine it with other erectile dysfunction medicines, including Malegra, Filitra, or Tadalista. Seek emergency care for chest pain, sudden vision or hearing loss, or an erection lasting longer than four hours. One question: Which strength of Cenforce are you taking — 25 mg, 50 mg, 100 mg, or a higher strength? The appropriate precautions depend on the dose and your health.