Duratia 90 mg contains dapoxetine, a medication used to treat premature ejaculation. It requires caution in liver disease because dapoxetine is extensively metabolized by the liver. Here's why liver disease matters: Reduced metabolism: Dapoxetine is primarily broken down by liver enzymes (mainly CYP2D6 and CYP3A4). If liver function is impaired, the drug is cleared more slowly. Higher drug levels: Slower clearance leads to increased concentrations of dapoxetine in the bloodstream, which can increase the likelihood and Duratia 90 mg of side effects. Greater risk of adverse effects: These can include dizziness, nausea, fainting (especially when standing up), headache, and drowsiness. In severe cases, the risk of serious side effects may increase. Because of this: Mild liver impairment: A healthcare provider may determine that dapoxetine can be used with caution in some cases. Moderate or severe liver impairment: Dapoxetine is generally not recommended (contraindicated) because the increase in drug exposure can be significant. If you have a liver condition or abnormal liver function tests, it's important to discuss them with the clinician who prescribed the medication before taking Duratia. They can determine whether it's appropriate or whether another treatment would be safer.